Chirality at a pro-pro-prochiral phosphorus center. Stereochemical course of the 5'-nucleotidase-catalyzed reaction
نویسندگان
چکیده
Journal of the American Chemical Society is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Chirality at a pro-pro-prochiral phosphorus center. Stereochemical course of the 5'-nucleotidase-catalyzed reaction Ming-Daw Tsai, and Ting-Ting Chang J. Am. Chem. Soc., 1980, 102 (16), 5416-5418• DOI: 10.1021/ja00536a061 • Publication Date (Web): 01 May 2002 Downloaded from http://pubs.acs.org on February 12, 2009
منابع مشابه
Use of phosphorus-31 nuclear magnetic resonance to distinguish bridge and nonbridge oxygens of oxygen-17-enriched nucleoside triphosphates. Stereochemistry of acetate activation by acetyl coenzyme A synthetase.
Adenosine 5'-(thiophosphate) AMPS) contains a prochiral phosphorus center. Differentiation of the two diastereotopic oxygens would allow elucidation of the stereochemical course of biological adenylyl transfer reactions. A general method was developed to distinguish between the "pro-R" and "pro-S" oxygens. When we converted the AMPS to the isomer A of adenosine 5'-(1-thiotriphosphate) (ATPalpha...
متن کاملEnzyme-catalyzed phosphoryl transfer reactions.
PERSPECTIVES AND SUMMARY ................... ... ...................................................... 877 Classes of enzyme involving reactions at phosphorus...................................................... 878 COVALENT REACTION INTERMEDIATES, CRYPTIC AND OTHERWISE........................................................................................................ 879 Reactions of Pho...
متن کامل7-Enriched Nucleoside Triphosphates. Stereochemistry of Acetate Activation by Acetyl Coenzyme A Synthetase?
Adenosine 5’-( thiophosphate) (AMPS) contains a prochiral phosphorus center. Differentiation of the two diastereotopic oxygens would allow elucidation of the stereochemical course of biological adenylyl transfer reactions. A general method was developed to distinguish between the “pro-R’ and “pro-S’ oxygens. When we converted the AMPS to the isomer A of adenosine S-( 1-thiotriphosphate) (ATP&),...
متن کاملThe stereochemical course at phosphorus of the reaction catalyzed by phosphoenolpyruvate carboxylase.
[(S)-16O,17O]Thiophosphoenolpyruvate has been used as a substrate in H218O for the reaction catalyzed by phosphoenolpyruvate carboxylase, and the absolute configuration of the product, inorganic [16O,17O,18O]thiophosphate, has been determined. The reaction proceeds with inversion of configuration at phosphorus, thus ruling out the cyclic mechanism that has been proposed for this enzyme. The ste...
متن کاملStereochemical Course of the Decarboxylation Catalyzed by Acetoacetate Decarboxylase
The stereochemical course of the decarboxylation of acetoacetate catalyzed by the enzyme acetoacetate decarboxylase (AAD) has been studied by using samples of optically active 2-tritioacetoacetate, prepared by enzymatic oxidation of samples of enantiomeric pairs of diastereomeric 2-tritio-3-hydroxybutyrates. A correlation is proposed connecting the stereochemical course of enzymatic decarboxyla...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009